![]() ![]() ![]() Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Protein chainmail: catenanted protein in viral capsids. Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Catenated circular DNA molecules in HeLa cell mitochondria. The present study thus details a simple approach to the creation and control of complex molecular architectures under reaction conditions that mimic biological milieux. In addition, the labile hydrazone linkages of the individual catenane components may be ‘locked’ by increasing the pH of the solution, yielding a relatively kinetically stable molecule. The quantitative synthesis process and the mechanically interlocked structure of the resulting catenane were established by NMR spectroscopy, mass spectrometry, X-ray crystallography and HPLC studies. Here, we present the preparation of a three-dimensional catenane through a self-assembly process that relies on the formation of dynamic hydrazone linkages in an acidic aqueous medium. However, the preparation of purely covalent molecular architectures in aqueous media has remained a challenging task. Self-assembly by means of coordinative bond formation has opened up opportunities for the high-yield synthesis of molecules with complex topologies. ![]()
0 Comments
![]() ![]() Readers are introduced, at first in a low-key way, to a milieu that encompasses pedophilia, homophobia and the sorts of subtle cruelties that may seem to sprout naturally in the setting of a boys’ school of this kind, where close contact provides fertile ground for adolescent discontent, dependency and an inbred atmosphere of bullying. ![]() Oswald’s for decades and that of a more sinister-sounding and anonymous diary writer who tells a chilling story about his time as a student at the school. Harris taught modern languages at a boys’ grammar school in England for 15 years, so she has nailed the musty, chalk-filled, stuck-in-time atmosphere dead-on.ĭifferent Class doesn’t read like a traditional, blood-and-guts thriller, but its slow-burning fuse has a deeper impact that readers absorb through two different, remarkable narratives: that of Latin teacher Roy Straitley, who’s been at St. Oswald’s, a not-quite-first-class boys’ grammar school located in Yorkshire. ![]() Though the story is a standalone, Different Class returns to geographical territory Harris explored in Gentlemen Players (2005) and Blueeyedboy (2010)-that of St. In Different Class, Harris has created an absorbing novel with a deep, dark mystery at its heart. The heading on Joanne Harris’ website remarks that she “does a bit of writing.” Many readers will recognize the understatement: Harris is the author of more than a dozen notable works, including the popular, award-winning novel Chocolat, which first brought Harris to the attention of American readers. ![]() ![]() ![]() Just as a single sick person can start an epidemic of the flu, so too can a small but precisely targeted push cause a fashion trend, the popularity of a new product, or a drop in the crime rate. The tipping point is that magic moment when an idea, trend, or social behavior crosses a threshold, tips, and spreads like wildfire. If you’re not familiar, here is more about The Tipping Point Gladwell, because I have finally read The Tipping Point. But now, I can go back to my unabashed bragging about my love for Mr. It has been a point of shame for me, I felt a little depressed that I wasn’t as much of a super fan of his work as I thought. ![]() I thought I had read all his books, but I had never actually read his first book, The Tipping Point. I’ve been proudly boasting that I love Malcolm Gladwell and that I’ve read all his books, and that he’s just the best. ![]() ![]() ![]() My journalistic work has appeared in publications including The Best American Science Writing, The New York Times, O: The Oprah Magazine, Los Angeles Times, San Francisco Chronicle, The Washington Post Magazine, Slate, Men's Journal, Self, and Outside, among others. My TED talk on fun was the 2nd most viewed TED talk for all of 2022 and, in a life highlight, I once led a virtual workshop on joy with Oprah Winfrey. ![]() Rowe Price, Alliance Health, Salesforce, and Hubspot, among many others. Kevin Roose at the New York Times once referred to me as "the Marie Kondo of brains."Īs a speaker, I've presented and led workshops for companies and organizations including TED, SXSW, Leadercast, Hyatt, Intel, Cigna, Morgan Stanley, The Children's Hospital of Philadelphia, Penguin Random House, T. I’m also the founder of, a resource hub dedicated to helping people create more intentional relationships with technology and reconnect with what really matters to them in life. I’m an award-winning science writer, speaker, workshop leader, consultant, and the author of books including The Power of Fun: How to Feel Alive Again, How to Break Up With Your Phone: The 30-Day Plan to Take Back Your Life, and Vitamania: How Vitamins Revolutionized the Way We Think About Food. ![]() I help people scroll less, live more, and have fun. ![]() ![]() ![]() ![]() An unspoken sense of community runs through the film, and the story reflects a time when the British Empire was weakening. Like other Ealing comedies, Whisky Galore! explores the actions of a small insular group facing and overcoming a more powerful opponent. Michael Balcon, the head of the studio, was unimpressed by the initial cut of the film, and one of Ealing's directors, Charles Crichton, added footage and re-edited the film before its release. It was filmed on the island of Barra the weather was so poor that the production over-ran its 10-week schedule by five weeks, and the film went £20,000 over budget. The islanders find out the ship is carrying 50,000 cases of whisky, some of which they salvage, against the opposition of the local Customs and Excise men. The story-based on a true event-concerns a shipwreck off a fictional Scottish island, the inhabitants of which have run out of whisky because of wartime rationing. It was the directorial debut of Alexander Mackendrick the screenplay was by Compton Mackenzie, an adaptation of his 1947 novel Whisky Galore, and Angus MacPhail. Whisky Galore! is a 1949 British comedy film produced by Ealing Studios, starring Basil Radford, Bruce Seton, Joan Greenwood and Gordon Jackson. ![]() ![]() ![]() ![]() ![]() dropcap W /dropcaphen the Civil War began, Harriet Tubman had already been a freedom fighter for more than a decade. With detailed narrative, this book covers her life from early days when she was a slave, to the years that she spent helping ensure the freedom of other slaves through means of the Underground Railroad. OL13624796W Page-progression lr Page_number_confidence 90.86 Pages 306 Ppi 514 Related-external-id urn:isbn:0316155942 The Legacy of Harriet Tubman: Freedom Fighter and Spy by Catherine Clinton Harriet Tubman helped plan a South Carolina river raid that freed hundreds of slaves. Harriet Tubman: The Road to Freedom examines the life and significance of Harriet Tubman. ![]() Access-restricted-item true Addeddate 22:13:35 Bookplateleaf 0004 Boxid IA173001 Boxid_2 CH114401 Camera Canon EOS 5D Mark II City New York, NY Donorīostonpubliclibrary Edition 1. ![]() ![]() ![]() ![]() His standards for adaptations of his novel were high, not only because, as the author of the original work, he was the best judge of the faithfulness of any later versions, but also because he had originally aspired to be a screenwriter. Puig reportedly disliked the film and hated the early version of the musical. ![]() To this day, the musical remains the best-known version of Puig’s novel, even though he had almost no input and died (in 1990) when the musical was still in its earliest workshop stage. The musical, despite a rocky start, eventually won four Tony awards, including Best Musical. The film was nominated for four Academy Awards and won a Best Actor award for William Hurt (as Molina). Yet it has had what one commentator (Isaac Butler, writing in The New Yorker in December 2022) has called “a remarkable afterlife.” Puig himself adapted the novel as a play in 1983 that play in turn inspired a film version in 1985, with a screenplay by Leonard Schrader and directed by Hector Babenco and finally, the novel was reimagined yet again as a Broadway musical in 1993, with music and lyrics by Kander and Ebb and the book by noted playwright Terrence McNally.Īll three of these later incarnations received considerable critical acclaim. Manuel Puig’s novel Kiss of the Spider Woman was a critical failure when it was first published in 1976. Miranda Johnson-Haddad, Resident Dramaturg at A Noise Within ![]() ![]() There are forests, castles, and lords or kings, minstrels, tinkers and wizards. ![]() McKillip's stories usually take place in a setting similar to the Middle Ages. She is married to David Lunde, a poet.Īccording to Fantasy Book Review, Patricia McKillip grew up in Oregon, England, and Germany, and received a Bachelor of Arts (English) in 1971 and a Master of Arts in 1973 from San Jose State University. Most of her recent novels have cover paintings by Kinuko Y. She is a past winner of the World Fantasy Award and Locus Award, and she lives in Oregon. Her writing u Patricia Anne McKillip was an American author of fantasy and science fiction novels, distinguished by lyrical, delicate prose and careful attention to detail and characterization. ![]() According to Fantasy Book Review, Patricia McKillip grew up in Oregon, England, and Germany, and received a Bachelor of Arts (English) in 1971 and a Master of Arts in 1973 from San Jose State University. ![]() Patricia Anne McKillip was an American author of fantasy and science fiction novels, distinguished by lyrical, delicate prose and careful attention to detail and characterization. ![]() ![]() ![]() In 2016, presidential candidate Donald Trump declared: "I think the big problem this country has is being politically correct." Reeling from his victory, Democrats blamed the corrosive effect of "identity politics." When banned from Twitter for inciting violence, Trump and his supporters claimed that the measure was an assault on "free speech." In We Need New Stories, Nesrine Malik explains that all of these arguments are political myths-variations on the lie that American values are under assault.Įxploring how these and other common political myths function, she breaks down how they are employed to subvert calls for equality from historically disenfranchised groups. ![]() ![]() From overhead in the giant fir came a twittering and rustling of grouse settling for the night and from across the valley drifted the last low calls of wild turkeys going to roost. Its music was pierced by the wild staccato yelp of a hunting coyote. Beneath him lay a narrow valley, open and grassy, from which rose a faint murmur of running water. Milt Dale, man of the forest, halted at the edge of a timbered ridge, to listen and to watch. Twilight appeared to come on its wings, as did faint sounds, not distinguishable before in the stillness. ![]() September in that latitude was marked by the sudden cool night breeze following shortly after sundown. It was a wild, richly timbered, and abundantly watered region of dark forests and grassy parks, ten thousand feet above sea-level, isolated on all sides by the southern Arizona desert - the virgin home of elk and deer, of bear and lion, of wolf and fox, and the birthplace as well as the hiding-place of the fierce Apache. Then, as the fire dropped behind the domed peak, a change, a cold and darkening blight, passed down the black spear-pointed slopes over all that mountain world. Old Baldy, highest of the White Mountains, stood up round and bare, rimmed bright gold in the last glow of the setting sun. At sunset hour the forest was still, lonely, sweet with tang of fir and spruce, blazing in gold and red and green and the man who glided on under the great trees seemed to blend with the colors and, disappearing, to have become a part of the wild woodland. ![]() |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |